Essentiality analysis
To constrain a reaction in a zero flux can simulate
the reaction deletion. Likewise, to constrain the reaction corresponding to a
deleted gene can simulate the gene deletion. GEMSiRV performs essentiality
analysis for gene and reaction separately and determines the rate ratio
(objective flux of deleted model to that of wild-type model) for every
single-knockout condition.
You can select a metabolic model for essentiality
analysis, the computational essential genes or reactions can be identified.
Results of gene
essentiality analysis:
Results of reaction
essentiality analysis: